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The Quantum State of Startup Pivots
Reflections from the edge of success
Apr 18
•
Joey DeBruin
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The Quantum State of Startup Pivots
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March 2025
Leeches, Cancer Abstracts, and Coming Home
Why now is the time to pursue problems you genuinely care about. Also, we’re hiring.
Mar 10
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Joey DeBruin
2
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Leeches, Cancer Abstracts, and Coming Home
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February 2025
AI Will Make Cold Outreach More Valuable, Not Less
The counterintuitive case for investing in outreach automation
Feb 25
•
Joey DeBruin
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AI Will Make Cold Outreach More Valuable, Not Less
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Where the AI-as-Employee Model Breaks
Agents don't onboard like humans, and that's a good thing for niche industries
Feb 19
•
Joey DeBruin
4
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Where the AI-as-Employee Model Breaks
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Will AI make science's reproducibility crisis worse?
Obviously — but is there room for optimism in the long run?
Feb 5
•
Joey DeBruin
1
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Will AI make science's reproducibility crisis worse?
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January 2025
How We’re Speedrunning Biotech Market Research with AI
A peek under the hood at the workflows we use to map a complex industry
Jan 28
•
Joey DeBruin
5
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How We’re Speedrunning Biotech Market Research with AI
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Build a Stylesheet to Make AI Actually Sound Like You
A simple hack to create consistent, authentic AI content (and a free tool to generate one from any Substack)
Jan 22
•
Joey DeBruin
5
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Build a Stylesheet to Make AI Actually Sound Like You
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The Opportunity for AI in Science Isn’t Where You Think
It’s finally time for bio tech
Jan 15
•
Joey DeBruin
3
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The Opportunity for AI in Science Isn’t Where You Think
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Software is Cheap. Clear problems aren’t.
On roboagencies and our bet on biotech
Jan 7
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Joey DeBruin
1
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Software is Cheap. Clear problems aren’t.
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December 2024
What happens when software gets 100X cheaper?
The end of tech debt (and other predictions)
Dec 17, 2024
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Joey DeBruin
3
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What happens when software gets 100X cheaper?
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Don't build another AI app
Build an AI interface (in a few days)
Dec 10, 2024
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Joey DeBruin
4
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Don't build another AI app
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Software is the new content marketing
Why companies should stop competing with creators and start building products
Dec 3, 2024
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Joey DeBruin
4
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Software is the new content marketing
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