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The Quantum State of Startup Pivots
Reflections from the edge of success
 • 
Joey DeBruin
Leeches, Cancer Abstracts, and Coming Home
Why now is the time to pursue problems you genuinely care about. Also, we’re hiring.
 • 
Joey DeBruin
AI Will Make Cold Outreach More Valuable, Not Less
The counterintuitive case for investing in outreach automation
 • 
Joey DeBruin
Where the AI-as-Employee Model Breaks
Agents don't onboard like humans, and that's a good thing for niche industries
 • 
Joey DeBruin
Will AI make science's reproducibility crisis worse?
Obviously — but is there room for optimism in the long run?
 • 
Joey DeBruin
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How We’re Speedrunning Biotech Market Research with AI
A peek under the hood at the workflows we use to map a complex industry
 • 
Joey DeBruin
Build a Stylesheet to Make AI Actually Sound Like You
A simple hack to create consistent, authentic AI content (and a free tool to generate one from any Substack)
 • 
Joey DeBruin
Flying Penguins
Flying Penguins
Decoding how great products will be built in an increasingly digital world

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